Redox State of T H E Mitochondrial Nad System in Cirrhosis of T H E Liver and in Chronic Quantitative
نویسنده
چکیده
I. To determine the redox state of the mitochondrial NAD system in cirrhosis of the liver and in chronic quanti tat ive undelnutrition, the substrates of the Lglutamate dehydrogenase (EC 1.4.1.2 ) and D-fl-hydroxybutyrate dehydrogenase (EC 1.1.1.3o) reactions were measured. The livers of animals fed ad l ib i tum served as controls. 2. Assuming these substrates to be in equilibrium, the NAD+/NADH ratio calculated from the substrates of the L-glutamate dehydrogenase reaction was lower in all three groups of animals than that calculated from the D-fl-hydroxybutyrate dehydrogenase reaction. On the other hand, the ratio
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